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. 2021 Jul 30;16:472. doi: 10.1186/s13018-021-02615-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Circ_0025908 knockdown inhibited RA progression. (A) The silencing efficiency of circ_0025908 was measured by qRT-PCR. (B) CCK8 assay was applied to evaluate the cell viability cells. (C) The EdU positive cell was detected by EdU assay. (D) Flow cytometry assay was carried out to explain the cell mitotic cycle. (E) The protein level of Ki67 and PCNA was examined by western blot. (F) Flow cytometry assay was employed to explain the apoptosis of RA cells. (G) The protein level of Bax and Bcl-2 were examined by western blot. (H-J) The level of IL-1β, IL-6, and TNF-α were measured by ELISA. (K) The protein levels of p-NF-KB p65 and total-NF-KB p65 were examined by western blot. *P < 0.05