Table 4.

Multivariable analysis taking the total FACT-Cog score as an independent variable

Model 1: Forward linear regression taking the depression score as the dependent variable (without forcing the genetic variables as independent variables)
Variable	UB	SB	p	95% Confidence Interval
Total FACT-Cog	−0.06	−0.32	< 0.001	−0.10	− 0.03
Sleep quality (PSQI score)	0.30	0.30	0.001	0.13	0.47
Fosaprepitant intake (yes vs no*)	−1.82	−0.19	0.026	−3.43	−0.22
*Reference group; Variables entered in Model 1: carboplatin, total Fact-Cog score, ISI score, PSQI score, fosaprepitant, OPRM1.
Model 2: Forward linear regression taking the depression score as the dependent variable (while forcing the genetic variables as independent variables).
Variable	UB	SB	p	95% Confidence Interval
Total FACT-Cog	−0.07	−0.33	0.001	−0.10	−0.03
Sleep quality (PSQI score)	0.33	0.32	0.001	0.14	0.52
Marital status (married vs single*)	−2.53	−0.21	0.029	−4.80	−0.27
Fosaprepitant intake (yes vs no*)	−2.15	−0.22	0.019	−3.94	−0.37
PER2 (AA vs GG*)	4.60	0.19	0.049	0.02	9.18
*Reference group; Variables entered in Model 2: Marital status, carboplatin, total Fact-Cog score, ISI score, PSQI score, fosaprepitant, CLOCK, PER2, CRY2, OPRM1, ABCB1, COMT, DRD2.
Model 3: Forward linear regression taking the anxiety score as the dependent variable (without forcing the genetic variables as independent variables).
Variable	UB	SB	p	95% Confidence Interval
Total FACT-Cog score	−0.07	−0.32	< 0.001	−0.11	− 0.03
Insomnia severity (ISI score)	0.19	0.26	0.003	0.07	0.32
Fosaprepitant intake (yes vs no*)	−2.17	−0.19	0.022	−4.02	−0.31
COMT Met/Met vs (Val/Val + Val/Met)*	1.09	0.17	0.042	0.04	2.14
*Reference group; Variables entered in Model 3: Carboplatin, cyclophosphamide, total Fact-Cog score, ISI score, PSQI score, fosaprepitant, OPRM1, COMT (Met/Met vs Val/Val + Val/Met).

Abbreviations: UB=Unstandardized Beta and SB=Standardized Beta