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. 2021 Jul 30;22:214. doi: 10.1186/s12931-021-01811-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — A representative photomicrographs (light microscopy) of kidney parenchyma stained with hematoxylin–eosin. Photomicrographs are representative of data obtained from kidney sections of 7 animals (original magnification, × 400). Bars = 100 μm. Note the presence of interstitial edema (asterisk), brush border lesion (two arrows), and cellular desquamation (one arrow). B kidney injury score; scores arithmetically averaged from two independent investigators representing injury from interstitial edema, vacuolization, brush border lesion, desquamation, and inflammation are shown. Boxes show the interquartile (25–75%) range, whiskers encompass the range (minimum to maximum), and horizontal lines represent median values of 7 animals/group