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. 2021 Jul 29;8(1):e000889. doi: 10.1136/bmjresp-2021-000889

Table 2.

Prognostic significance of clinical parameters in patients with AE-IIPs determined by logistic regression analysis

Parameter OR* 95% CI P value
Univariate
Stable state
 Sex, male/female 1.2499 0.2060 to 10.2093 0.8140
 Smoking, yes/no 2.2400 0.4135 to 12.3435 0.7376
 Diagnosis, IPF/non-IPF 0.6190 0.0765 to 3.5887 0.6037
 mMRC, ≤1/≥2 1.1666 0.2251 to 6.9237 0.8560
 Stage, I–III/IV 2.7083 0.5354 to 14.8724 0.2275
 LTOT before AE, yes/no 2.7083 0.5354 to 14.8724 0.2275
 Prednisolone before AE, yes/no 2.2400 0.4135 to 12.3435 0.3431
 Antifibrotic drugs before AE, yes/no 14.400 1.6803 to 319.0268 0.0137
At the time of diagnosis of AE
 Age, years 0.9929 0.8995 to 1.0986 0.8863
 HRCT pattern, diffuse/non-diffuse 9.8000 1.7196 to 83.0325 0.0091
 PaO2/FiO2 ratio, ≤200/>200 0.7291 0.1425 to 3.8110 0.7014
 WCC, /μL 1.0001 0.9999 to 1.0004 0.1607
 LDH, U/L 1.0065 1.0007 to 1.0145 0.0244
 KL-6, U/mL 1.0009 1.0001 to 1.0020 0.0146
 CRP, mg/dL 0.9678 0.8582 to 1.0777 0.6268
 FDP, ≥10/<10 mg/L 4.2666 0.7166 to 28.9076 0.1102
Multivariate†
 HRCT pattern, diffuse/non-diffuse 13.3634 1.7053 to 285.2057 0.0118
 Antifibrotic drugs before AE, yes/no 21.3180 1.6243 to 860.5019 0.0179

*An OR >1 means each categorical parameter or increase in each continuous parameter indicates a high risk of 90-day mortality.

†Multivariate analysis with a stepwise selection procedure was performed to predict 90-day survival using significant parameters with a p value <0.05.

AE, acute exacerbation; CRP, C reactive protein; FDP, fibrin degradation product; FiO2, fraction of inspired oxygen; HRCT, high-resolution CT; IIPs, idiopathic interstitial pneumonias; IPF, idiopathic pulmonary fibrosis; KL-6, Krebs von den Lungen-6; LDH, lactate dehydrogenase; LTOT, long-term oxygen therapy; mMRC, modified Medical Research Council score; PaO2, arterial oxygen tension; WCC, white blood cell count.