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. 2021 Jul 29;9(7):e002968. doi: 10.1136/jitc-2021-002968

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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CD200⁺ alters T cell composition in vivo. (A) CyTOF summary UMAP of healthy human immune cells derived from humanized mice with cluster definitions. (B) Cluster proportions for each mouse. (C) Clusters with significantly different frequency between mice with CD200⁺ and CD200⁻ disease (Wilcoxon test). (D) Heatmap of average protein intensity for all markers by cluster and disease status. (E) Density plots of Ki67 expression in cells from CD8 CM 2 and EM 1 clusters for each mouse evaluated (left) and summarized for all cells from a specific disease group (right; Wilcoxon test). *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.