Figure 7.
α-mangostin inhibits tumor growth in 143B xenografted mice. 143B cells (5 × 106/0.1 ml/mouse) were subcutaneously injected into mice. When the tumors had reached an average volume of 200 mm3, α-mangostin of different concentrations were intraperitoneally injected at 5 and 20 mg/kg (dissolved in 0.2 ml olive oil) once a day until the mice were killed. (A) Tumor volume was measured every 3 days for 21 days. (B) At the end of the experiment, mice were sacrificed, and tumors were excised to measure the weight. (C–F) The protein levels of cleaved-caspase-3/8, Wnt3a, p-Gsk3β, nuclear β-catenin, CHOP and ATF6 were determined. N = 10, *P < 0.05, **P < 0.01.