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A schematic diagram for the role of α-mangostin on osteosarcoma cell apoptosis. By increasing ROS level, α-mangostin induced ER stress and impeded the nuclear accumulation of β-catenin. Then, the caspase3/8 cascade was activated, and OS cell apoptosis was increased. Moreover, α-mangostin also inhibited the nuclear transport of β-catenin by restraining Wnt3a. NAC treatment could effectively eliminate the generation of ROS induced by α-mangostin.
