Figure.

Timeline of events in a case of breakthrough infection in a fully vaccinated HCW and onward transmission of SARS-CoV-2 Beta (B.1.351) variant to unvaccinated spouse, Bavaria, Germany, February to March 2021

Anti-N AB: antibodies against anti-nucleocapsid protein; Anti-S AB: antibodies against anti-spike protein; HCW: healthcare worker; NAb: neutralising antibody; neg: negative; pos: positive; RT: reverse transcriptase; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; SEQ: sequencing; SNP: single nucleotide polymorphisms.

^a Corrected NAb titre from triplicates in cell culture.

^b SEQ and was performed and all nine defining SNPs for SARS-CoV-2 B.1.351 (Beta) variant (E:P71L, N:T205I, orf1a:K1655N, S:D80A, S:D215G, S:K417N, S:A701V, S:N501Y, S:E484K) were identical.