Table 2.

Univariate and multivariate Cox analyses showed risk score is an independent risk factor

variables	Univariate Cox analysis		Multivariate Cox analysis
	P-value	HR (95% CI)	P-value	HR (95% CI)
Age	0.001*	1.808 (1.324–2.47)	0.061	1.598 (0.978–2.610)
Gender	0.757	0.953 (0.702–1.294)	0.078	0.610 (0.352–1.058)
Pathological stage	2e−16*	3.912 (2.857–5.362)	0.048*	3.303 (1.028–10.949)
Pathological T stage	3.8e−16*	3.204 (2.369–4.331)	0.272	0.573 (0.212–1.546)
Pathological M stage	2e−16*	4.254 (3.117–5.805)	0.035*	1.957 (1.048–3.655)
Pathological Grade	3.42e−08*	2.598 (1.851–3.646)	0.217	1.462 (0.804–2.633)
Four-miRNA signature	2.14e−08*	4.628 (2.707–7.911)	4.23e−05*	4.324 (2.385–7.839)