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. Author manuscript; available in PMC: 2021 Jul 30.
Published in final edited form as: ACS Chem Biol. 2020 Dec 9;15(12):3176–3186. doi: 10.1021/acschembio.0c00707

Figure 1. Glycolipid structures and synthesis of C4” amide linked derivatives of α-GalCer.

Figure 1.

A) KRN7000 is the prototypical α-GalCer antigen for iNKT cells. AH10-7 is a C6”-modified α-GalCer prepared and evaluated by us previously. Compounds 1–7 are representative C4”-modified α-GalCer derivatives previously described in the literature (see text for references). Amides 8–10 are the focus of this work. B) Synthetic strategy for the preparation of 8–10.