Figure 14.

Effects of exendin-4 and DA-CH5 on 6-OHDA-induced reductions in autophagy-related protein expression in the rat SN.

(A) Bands of autophagy-related protein expression in SN lysates as detected by western blot assay. GAPDH was used as the loading control. SQSTM1 (B) and Beclin-1 (C) expression in SN lysates. Data are shown as the mean ± SD of four rats per group, and were analyzed by one-way analysis of variance followed by Tukey’s multiple comparison test. ‡P < 0.05, ‡‡P < 0.01, ‡‡‡P < 0.001, vs. sham group; $P < 0.05, $$P < 0.01, vs. 6-OHDA group; &&P <0.01, vs. 6-OHDA + exendin-4 group (one-way analysis of variance followed by Tukey’s multiple comparison test). 6-OHDA: 6-Hydroxydopamine; exendin-4 and DA-CH5: glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual receptor agonist; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; PD: Parkinson’s disease; SN: substantia nigra; SQSTM1: sequestosome 1.