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. 2021 Jun 18;144(5):353–364. doi: 10.1161/CIRCULATIONAHA.121.053797

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© 2021 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 2. — Genes associated with circulating levels of extra-small very-low-density lipoprotein particle concentration (XS.VLDL.P) and large low-density lipoprotein particle concentration (L.LDL.P) lipoprotein subfractions. Transcriptome-wide association studies were performed integrating liver gene expression data from Genotype-Tissue Expression version 8 with genome-wide association study (GWAS) summary statistics for XS.VLDL.P and L.LDL.P to identify genes associated with circulating levels of each lipoprotein subfraction. A, Genes significantly (false discovery rate [FDR] <0.05) associated with either subfraction are labeled, and colors represent the subfraction associations. B, Bar plot depicts the number of unique and shared genes between the 2 subfractions. C, Forest plot depicts the z score for the difference in the effect magnitude for each gene on each subfraction (|β_XS.VLDL.P|−|β_L.LDL.P|). Dotted lines represent z scores of ±1.96, with point estimates outside this range representing significant (P_diff<0.05) differential effects. Error bars represent 95% CIs for the z score.