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. 2021 Jul 30;11(7):136. doi: 10.1038/s41408-021-00528-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Antibody responses to SARS-COV19 Spike following first vaccine in sera from healthy donors (HD) and patients with CLL, as measured by Roche assay. Red indicates those previously exposed (PE) to SARS-CoV-2 (median HD 41.6 vs CLL 0.4 (104 fold change)); cut off for positivity at 0.8 shown by dotted line. B Antibody responses to SARS-CoV-2 Spike in patients with CLL following first vaccine, by management stage, as measured by Roche (Total patients; Watch and Wait (W+W); Previous Chemo-immunotherapy but not on active therapy (pCI); Bruton Tyrosine Kinase therapy (BTKi); Venetoclax therapy (Ven); Treatment planned (TP). C Bar chart to show the percentage response after first vaccine in healthy donors and CLL measured by Roche. D Antibody responses to SARS-CoV-2 Spike from DBS in healthy donors (HD) and patients with CLL, as measured by The Binding Site (TBS) assay using DBS eluates (median 1 vs 0.5; p < 0.0001; (cut off positivity shown at 1). E Antibody responses to SARS-CoV-2 Spike in patients with CLL following first vaccine, by management stage, as measured by TBS using DBS eluates (Kruskal–Wallis p = 0.0054; post hoc Dunn’s analysis p < 0.0056 W+W vs BTKi). F Bar chart to show the percentage response after first vaccine in HD and CLL measured by TBS using DBS eluates.