Table 2.

Cycloisomerization of 18–20: variation of R under a variety of conditions.

Entry	Substrate	Conditionsa	Time	Conversionb
1	18	1, + AgOTf, 70 °C	1 h	15%
		1, + AgOTf, 70 °C	16 h	99%
2	18	2 + AgOTf, 70 °C	1 h	7%
		2 + AgOTf, 70 °C	16 h	99%
3	19	1, + AgOTf, 70 °C	1 h	0%
		1, + AgOTf, 70 °C	16 h	50%
4	19	2 + AgOTf, 70 °C	1 h	0%
		2 + AgOTf, 70 °C	16 h	37%
5	20	1, + AgOTf, 70 °C	16 h	0%

^a[Substrate] = 0.04 mM, [Au] = 0.002 mM (0.05 mol%) [additive] = 0.004 mM (0.1 mol%), reaction volume 0.60 mL.

^bAs determined by NMR integration, all species were cleanly resolved, the only observable compounds were starting [Substrate] or product 26.