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. 2021 Jul 30;16(7):e0255513. doi: 10.1371/journal.pone.0255513

Table 2. Clinical course of disease.

All patients Asymptomatic patients Mild (symptomatic outpatients) Moderate (hospitalized) Critical (ventilation) Deceased
n (%) 897 (100) 54 (6.0) 713 (79.5) 97 (10.8) 16 (1.8) 17 (1.9)
Symptoms#
n (%)
    1. Fever 481 (53.6) Asymptomatic 374 (52.5) 82 (84.5) 13 (81.3) 12 (70.6)
    2. Cough 552 (61.5) 457 (64.1) 72 (74.2) 9 (56.3) 14 (82.4)
    3. Sputum 79 (8.8) 75 (10.5) 10 (10.3) 3 (18.8) 1 (5.9)
    4. Sore throat 306 (32.1) 269 (37.7) 32 (33.0) 5 (31.3) 1 (5.9)
    5. Dyspnea 181 (20.1) 113 (15.8) 50 (51.5) 10 (62.5) 8 (47.1)
    6. Muscle pain 279 (31.1) 242 (33.9) 27 (27.8) 8 (50.0) 2 (11.8)
    7. Limb pain 432 (48.1) 373 (52.3) 47 (48.5) 10 (62.5) 2 (11.8)
    8. Fatigue 586 (65.3) 524 (73.5) 64 (66.0) 9 (56.3) 11 (64.7)
    9. Headache 513 (57.2) 450 (63.1) 53 (54.6) 8 (50.0) 2 (11.8)
    10. Runny nose 270 (30.1) 253 (35.5) 15 (15.5) 2 (12.5) 0 (0.0)
    11. Chest pain 154 (17.1) 135 (18.9) 15 (15.5) 2 (12.5) 2 (11.8)
    12. Diarrhea 212 (23.6) 173 (24.3) 29 (29.9) 5 (31.3) 5 (29.4)
    13. Nausea 96 (10.7) 77 (10.8) 14 (14.4) 3 (18.8) 2 (11.8)
    14. Change in taste 537 (59.8) 480 (67.3) 50 (51.5) 6 (37.5) 1 (5.9)
    15. Other 304 (33.9) 259 (36.3) 20 (20.6) 4 (25.0) 2 (11.8)
Comorbidities n (%)
Cardiac disease 197 (22.0) 14 (25.9) 119 (16.7) 39 (40.2) 12 (75.0) 13 (76.5)
    Hypertension 152 (17.0) 9 (16.7) 98 (13.7) 29 (29.9) 6 (37.5) 10 (58.8)
    CHD 19 (2.1) 2 (3.7) 7 (1.0) 2 (2.1) 2 (12.5) 6 (35.3)
Lung disease 124 (13.8) 8 (14.8) 87 (12.2) 22 (22.7) 4 (25.0) 3 (17.7)
Kidney disease 24 (2.7) 3 (5.6) 13 (1.8) 4 (4.1) 2 (12.5) 2 (11.8)
Liver disease 13 (1.5) 1 (1.9) 6 (0.8) 5 (5.2) 1 (6.3) 0 (0.0)
Diabetes mellitus 44 (4.9) 4 (7.4) 25 (3.5) 9 (9.3) 4 (25.0) 2 (11.8)
Autoimmune disorder 52 (5.8) 3 (5.6) 40 (5.6) 8 (8.3) 1 (6.3) 0 (0.0)
HIV positive 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0)
Malignancy 49 (5.5) 5 (9.3) 26 (3.7) 14 (14.4) 1 (6.3) 3 (17.7)
Other 168 (19) 8 (14.8) 129 (18.1) 27 (27.8) 5 (31.3) 9 (52.9)
Medication n (%)
Any 346 (38.6) 20 (37.0) 271 (38.0) 40 (41.2) 10 (62.5) 5 (29.4)
NSAR 71 (7.9) 7 (13.0) 51 (7.2) 8 (8.3) 2 (12.5) 3 (17.7)
ACEI 52 (5.8) 4 (7.4) 30 (4.2) 12 (12.4) 5 (31.3) 1 (5.9)
AT1-Inhibitors 82 (9.1) 6 (11.1) 60 (8.4) 13 (13.4) 3 (18.8) 0 (0.0)
Immunosuppressants 42 (4.7) 1 (1.9) 32 (4.5) 9 (9.3) 0 (0.0) 0 (0.0)
Chemotherapy 1 (0.1) 0 (0.0) 0 (0.0) 1 (1.0) 0 (0.0) 0 (0.0)
Smoking n (%)
Never 533 (59.4) 40 (74.1) 442 (62.3) 43 (44.3) 5 (31.3) 3 (17.7)
Former 246 (27.4) 8 (14.8) 198 (27.8) 32 (33.0) 6 (37.5) 2 (11.8)
Current 82 (9.1) 5 (9.3) 71 (10.0) 5 (5.2) 0 (0.0) 1 (5.9)
Missing 36 (4.0) 1 (1.9) 2 (0.3) 17 (17.5) 5 (31.3) 11 (64.7)
Days from illness onset to diagnosis Mean (SD) 6 (4) x 6 (4) 6 (4) 8 (2) 7 (4)
Days from illness onset to recovery Mean (SD) 14 (8) x 14 (7) 19 (9) 19 (8) x

Clinical characteristics and history of 897 participants with coronavirus disease 19 stratified by level of severity. Data are either numbers (percentages) or means (standard deviations) as indicated in the table. Given symptoms are pooled symptoms comprising of initial and developed symptoms. See S2 Table for further details.