Table 5. Rearranged PDAC tumor samples showing the continuously changing pattern of the signature profile.

Columns are sorted based on APOD rankings. Genes APOD and COL11A1 are highlighted in green and red, respectively.

Rank	T2	T13	T14	T19	T3	T10	T15	T18	T7	T6	T12	T4	T24	T1	T5	T22	T11	T21	T23	T9	T16	T17	T8
1	LUM	LUM	DCN	SFRP2	MMP2	PDGFRA	SFRP2	DCN	CYP1B1	COL10A1	MMP2	COL10A1	DCN	SFRP2	PDGFRA	COL1A2	LUM	COL10A1	COL1A1	LUM	LUM	COL10A1	COL11A1
2	APOD	APOD	APOD	APOD	LUM	HTRA3	LUM	SFRP2	SFRP2	PDGFRA	LUM	SFRP2	LUM	VCAN	CYP1B1	PDGFRA	DCN	CTHRC1	COL1A2	DCN	DCN	CTHRC1	COL10A1
3	VCAN	DCN	LUM	LUM	APOD	DPT	DCN	LUM	COL8A1	SFRP2	PDGFRA	COL1A1	FBLN1	LUM	SFRP2	THBS2	CTHRC1	THBS2	COL3A1	RARRES2	COL1A1	COL11A1	CREB3L1
4	SFRP4	FBLN1	SFRP4	IGF1	DCN	APOD	VCAN	C3	PDGFRA	CYP1B1	CTHRC1	MMP2	VCAN	PDGFRA	SFRP4	MMP2	SFRP2	GJB2	COL6A3	CTHRC1	COL1A2	ISLR	RP11-400N13.3
5	SFRP2	MMP2	TSHZ2	EFEMP1	FBLN1	MEG3	APOD	MMP2	COL10A1	MMP2	ITGBL1	LUM	SFRP4	COL1A2	DPT	COL1A1	COL10A1	SFRP2	LUM	SFRP2	COL6A3	MMP2	SFRP2
6	MMP2	SFRP4	HTRA3	PDGFRA	VCAN	OMD	FBLN1	APOD	SFRP4	VCAN	EFEMP1	COL1A2	COL1A2	EFEMP1	LUM	COL3A1	RARRES2	COL11A1	FN1	AEBP1	COL3A1	COL1A1	BASP1
7	RARRES1	SFRP2	FBLN1	OGN	FBLN5	ITGBL1	MMP2	EFEMP1	CTHRC1	CTHRC1	SFRP2	CTHRC1	MMP2	DCN	MEG3	ITGBL1	AEBP1	CCDC80	COL5A2	COL10A1	VCAN	COL1A2	PDPN
8	C3	RARRES1	MMP2	SFRP4	PDGFRA	PAPPA	COL6A3	MFAP4	APOD	LUM	FBLN5	DCN	SFRP2	CCDC80	EFEMP1	COL10A1	NBL1	NBL1	VCAN	NBL1	SFRP2	COL3A1	BNC2
9	MEG3	VCAN	COL6A3	VCAN	SFRP2	MRC2	COL1A1	FBLN1	MMP2	SFRP4	VCAN	CTSK	C1R	ISLR	VCAN	CTHRC1	CTSK	DCN	COL5A1	MMP2	MEG3	AEBP1	C5orf46
10	HTRA3	HTRA3	VCAN	CTSK	C3	LSAMP	COL1A2	SFRP4	PLXDC2	APOD	APOD	MFAP2	C1S	SFRP4	IGF1	LUM	VCAN	AEBP1	THBS2	CTSK	CTHRC1	MMP11	PLXDC2
11	FBLN1	ISLR	GPC3	COL1A2	MGP	CYP1B1	ISLR	CCDC80	VCAN	PLXDC2	COL8A1	APOD	APOD	COL6A3	FBLN5	SFRP2	CTGF	INHBA	SFRP2	THBS2	EFEMP1	THBS2	SPOCK1
12	MGP	COL6A3	CTGF	STEAP1	EFEMP1	COL10A1	COL10A1	RARRES1	BNC2	COL8A1	STEAP1	MATN3	CTSK	CYP1B1	SERPINE2	EFEMP1	COL8A1	LUM	CTHRC1	FBLN1	PDGFRA	COL12A1	ADM
13	DCN	SPON2	SFRP2	MMP2	OMD	COL8A1	CTHRC1	C1S	MRC2	FBLN1	COL1A2	MEG3	CCDC80	COL1A1	FBLN1	MRC2	THBS2	FBLN1	MMP2	VCAN	FBLN2	HTRA1	MMP2
14	CYP1B1	CYP1B1	C1S	CYP1B1	RP11-572C15.6	PDPN	CCDC80	VCAN	DPYSL3	OMD	PTGDS	ISLR	ISLR	APOD	SCN7A	COL6A3	MMP2	MMP2	COL10A1	CCDC80	LOX	MMP14	ARL4C
15	COL1A2	LXN	OMD	PTGDS	CCDC80	CXCL14	SFRP4	PTGDS	COL1A2	THBS2	ISLR	FBLN1	C3	CLDN11	LTBP2	PDPN	COL11A1	COL6A3	COL11A1	COL1A1	COL5A1	SFRP2	MEG3
16	MOXD1	SERPINF1	SPON2	FBLN1	IGF1	MMP23B	CTSK	C1R	FBLN5	FAP	LXN	COL11A1	EFEMP1	CTSK	APOD	VCAN	INHBA	OMD	AEBP1	S100A6	COL8A1	SULF1	GJA1
17	PTGDS	CTHRC1	C3	RARRES1	TSHZ2	ABCA9	COL3A1	CTSK	CREB3L1	MFAP2	OLFML3	COL3A1	MGP	FBLN1	PTGDS	DPYSL3	C1QTNF3	MEG3	COL12A1	COL8A1	LXN	LUM	VCAN
18	FBLN5	CTSK	F2R	DCN	ITM2A	LUM	S100A10	PDGFRA	COL3A1	COL6A3	THBS2	SFRP4	TSHZ2	MMP2	ISLR	LOX	SFRP4	COL8A1	DCN	TMSB10	MMP2	SDC1	FIBIN
19	PDGFRA	F2R	ANKH	COL3A1	SFRP4	PDGFRL	THBS2	SERPINF1	OMD	RARRES1	FBLN1	CXCL14	PDGFRA	COL3A1	PODN	GJA1	MATN3	ISLR	SPARC	C1S	S100A10	DCN	COL1A2
20	COL6A3	FBLN5	CTSK	MFAP5	RARRES1	STXBP6	HTRA1	MOXD1	RARRES1	EFEMP1	MGST1	ITGBL1	OMD	PTGDS	DCN	APOD	HTRA1	MMP11	TMSB10	COL1A2	FBLN1	MFAP5	ZFHX4
21	CTHRC1	COL1A2	C1R	FBLN5	COL8A1	SVEP1	SEMA3C	GPNMB	PODN	COL1A2	MEG3	COL6A3	FBLN5	FBLN2	MMP2	FAP	ITGBL1	MFAP5	MMP14	COL3A1	ISLR	VCAN	MFAP2
22	FAP	C7	IGFBP3	COL1A1	OGN	BICC1	FBLN2	RARRES2	LSAMP	ANKH	PDPN	VCAN	COL1A1	CTHRC1	MGP	MXRA5	MFAP5	PPAPDC1A	SDC1	HTRA1	FAP	COL6A3	MME
23	F2R	TMEM119	MOXD1	ISLR	C7	ABCA6	LRP1	FBLN5	THBS2	FNDC1	MFAP2	IGFL2	OGN	C3	C7	PODN	CXCL14	CTSK	POSTN	CD99	PPIC	GJB2	MFAP5
24	ISLR	EFEMP1	CTHRC1	C3	DPT	MFAP2	MRC2	ISLR	SVEP1	SPON2	DPT	RARRES2	SERPINF1	PLXDC2	MGST1	CXCL14	GJB2	MXRA5	FBLN1	ISLR	CYP1B1	GREM1	RAB3B
25	TIMP1	MOXD1	MEG3	MEG3	BICC1	BNC2	PDPN	ITGBL1	ITGBL1	PDPN	C3	FNDC1	CTGF	RARRES1	SPOCK1	COL8A1	IGFBP3	FNDC1	INHBA	SERPINF1	CREB3L1	TIMP2	ITGBL1
26	C7	CCDC80	PDGFRA	CTHRC1	CTHRC1	WNT5A	MXRA5	COL10A1	PTGDS	CTSK	MRC2	COL5A1	FBLN2	RP11-572C15.6	CCDC80	SFRP4	CCDC80	COL1A1	SERPINH1	TSC22D3	CCDC80	COL5A2	GJB2
27	PHLDA3	COL1A1	FBLN5	MOXD1	PODN	CST3	OMD	CYP1B1	FAP	MFAP5	PTGIS	OMD	COL6A3	THBS2	SLC19A2	SEMA3C	CD99	SDC1	MXRA5	FTL	MRC2	FAP	COL3A1
28	OMD	PLXDC2	ITM2A	COL6A3	COL6A3	SFRP2	ITGBL1	C7	LUM	HTRA3	MOXD1	CST4	PODN	C7	HTRA3	LRP1	C1S	VCAN	HTRA1	MFAP2	MFAP5	MFAP2	NTM
29	FBLN2	PDGFRA	COL1A2	MGP	CXCL14	MOXD1	RARRES2	PLXDC2	FBLN1	LRP1	HSD11B1	INHBA	LTBP2	LAMA2	MOXD1	NTM	LOXL1	GREM1	MMP11	ANXA2	THBS2	CTSK	PDLIM4
30	SCN7A	C3	PTGDS	C7	COL1A2	ZFHX4	FBN1	CTHRC1	SULF1	COL1A1	SFRP4	GJB2	ITGBL1	OLFML3	ITGBL1	C3	FIBIN	PDPN	ISLR	LAPTM4A	CTSK	COL5A1	CMTM8
31	EFEMP1	COL10A1	RARRES1	CILP	ISLR	RARRES1	PLXDC2	DPT	INHBA	DIO2	LSAMP	IGFBP3	C7	MFAP4	CTSK	COL11A1	FBLN1	FBLN2	MEG3	NNMT	MXRA5	PPAPDC1A	TANC2
32	COL10A1	C1S	OLFML3	COL8A1	MEG3	BOC	CXCL14	CLU	SEMA3C	DCN	PLXDC2	HTRA3	PLXDC2	SLIT2	FBLN2	UNC5B	PALLD	MFAP2	TIMP2	C1R	OGN	FN1	NT5E
33	SERPINF1	PODN	OGN	THBS2	CTSK	PODN	PDGFRA	NPC2	LOX	ALDH1A3	MFAP4	CST1	MOXD1	IGF1	CTHRC1	LOXL1	SDC1	C1QTNF3	FSTL1	RPL27A	RARRES2	TMEM158	TENM3
34	BNC2	LTBP2	ITGBL1	MRC2	HSD11B1	TMEM119	MATN3	MEG3	PDPN	LOX	OGN	FBLN2	TMEM119	LRP1	SVEP1	COL5A2	MFAP2	COL5A2	COL6A2	INHBA	FSTL1	POSTN	EPDR1
35	CTSK	NPC2	PTCH1	NR2F1	CTGF	PTGIS	COL8A1	RP11-572C15.6	IGF1	FBLN2	COL6A3	MFAP5	COL8A1	PDLIM3	MXRA5	SCARA3	ANXA2	CDH11	CTSK	NUPR1	COL5A2	ANTXR1	MYH10
36	MRC2	HSD11B1	COL8A1	ITGBL1	C1S	OGN	NBL1	MGP	LAMP5	OLFML3	SPON2	MXRA5	LRP1	LTBP2	STEAP1	COL8A2	APOD	LOX	MFAP2	LGALS1	LRP1	PLAU	LOX
37	TSHZ2	MGP	BOC	TSHZ2	COL10A1	FAP	TMEM119	COL6A3	FBLN2	TMEM119	COL1A1	THBS2	RARRES1	FBLN5	NEGR1	PTGDS	OMD	COL3A1	MFAP5	COL6A3	RARRES1	INHBA	COL8A1
38	LRP1	DPT	SERPINF1	STEAP2	SERPINE2	EFEMP1	HTRA3	LTBP2	OGN	MEG3	LTBP2	CTGF	BOC	MGP	C3	CCDC80	ISLR	PDGFRA	GAS1	COL11A1	FBLN5	GJA1	EVA1A
39	SLIT2	COL3A1	MGP	MFAP2	SERPINF1	LAMA2	FAP	AEBP1	PTGFRN	FGF7	PODN	MRC2	CYBRD1	MEG3	RARRES1	ALDH1A3	SLC6A6	F13A1	LRRC15	OMD	FBN1	LGALS1	MXRA5
40	COL1A1	OMD	IGFBP6	PDGFRL	LTBP2	GSTM5	MEG3	PDPN	GAS7	TMSB10	DCN	GJA1	LXN	BICC1	RP11-572C15.6	FGFR1	CYR61	FRMD6	COL8A2	CD55	GAS1	PTK7	BICC1
41	SVEP1	MFAP4	TIMP1	PDPN	NEGR1	IGF1	FNDC1	COL1A1	CXCL14	CXCL14	CTSK	FAP	LOX	MRC2	PLXDC2	BOC	COL1A2	APOD	FBLN2	PDPN	BNC2	CD99	C1orf198
42	THBS2	TSHZ2	MFAP4	PLXDC2	MOXD1	F2R	NTM	COL8A1	COL11A1	ITGBL1	SPOCK1	SPON2	HTRA3	FGFR1	LRP1	PLXDC2	MMP11	COL1A2	GREM1	LOXL1	PLOD2	NBL1	INHBA
43	TMEM119	COL8A1	CLEC11A	OMD	C1R	F3	DPYSL3	S100A13	FNDC1	IGFBP3	COL3A1	BICC1	RP11-572C15.6	ABL2	ABI3BP	MFAP2	MEG3	DIO2	APOD	FIBIN	PDPN	NTM	PDGFC
44	IGFBP3	STEAP1	INHBA	MMP23B	FGF7	MMP2	SLC6A6	OGN	HTRA3	CDH11	RARRES1	EMP1	CYP1B1	MXRA5	FAP	MFAP5	PLXDC2	CD55	COL8A1	NTM	MMP23B	RARRES2	FBLN2
45	C1S	PTGDS	MXRA8	LXN	COL1A1	SFRP4	CYP1B1	MMP23B	MOXD1	IGF1	SVEP1	FGF7	CTHRC1	RGS2	COL6A3	TMSB10	FBLN2	HTRA1	CD99	S100A10	LTBP2	FBLN1	B4GALT1