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Avibactam Inhibitory Concentrations (IC50) Using Crude Protein Extracts from E. coli Producing the Different Variants and Wild-Type PenA1a
| β-lactamase | avibactam IC50 (μM) |
|---|---|
| PenA1 | 1 |
| R220A | 31 |
| T237A | 0.12 |
| S130A | >500 |
| K234A | >800 |
| N170A | 2.6 |
| D276A | 1 |
100 μM nitrocefin was used for all trials as the substrate.
