Table 1.
Demographic and Clinical Characteristics of HAdV-B and HAdV-C Species in Symptomatic Cases Seen at Vanderbilt Children’s Hospital Over a 14-Month Period (May 2018–June 2019)€.
| Characteristics | All Speciesλ (n = 237) % (n) | HAdV-B (n = 104) % (n) | HAdV-C (n = 114) % (n) | p-value |
|---|---|---|---|---|
| Mean age, months (SD) | 39.2 (39.7) | 55.9 (41.4) | 20.9 (25.6) | <0.005 |
| Male sex | 60 % (142) | 58 % (60) | 60 % (68) | 0.769 |
| Race | ||||
| White | 75 % (165) | 80 % (74/92) | 71 % (77/108) | 0.053 |
| Black/African American | 16 % (35) | 10 % (9/92) | 22 % (24/108) | |
| Other | 9% (19) | 10 % (9/92) | 6% (7/108) | |
| Hispanic ethnicity | 19 % (44/230) | 24 % (24/102) | 17 % (18/109) | 0.202 |
| Childcare attendance | 57 % (90/159) | 60 % (40/67) | 54 % (43/79) | 0.522 |
| Underlying medical conditions§ | 32 % (76) | 31 % (32) | 33 % (38) | 0.685 |
| Fever | 94 % (223) | 95 % (99) | 94 % (107) | 0.667 |
| Rash | 11 % (26) | 14 % (15) | 8% (9) | 0.124 |
| Conjunctivitis | 18 % (42) | 28 % (29) | 11 % (12) | 0.001 |
| Cough | 67 % (158) | 67 % (70) | 69 % (79) | 0.752 |
| Dyspnea on physical exam | 11 % (27) | 8% (8) | 15 % (17) | 0.095 |
| Chest retraction on physical exam | 12 % (29) | 9% (9) | 16 % (18) | 0.110 |
| Wheezing on physical exam | 5% (12) | 4% (4) | 5% (6) | 0.617 |
| Seizure | 6% (14) | 3% (3) | 10 % (11) | 0.042 |
| Admitted in hospital | 33 % (79) | 25 % (26) | 43 % (49) | 0.005 |
| Oxygen requirement | 29 % (23/79) | 23 % (6/26) | 33 % (16/49) | 0.386 |
| ICU admission | 11 % (9/79) | 4% (1/26) | 14 % (7/49) | 0.163 |
| Mean duration of hospital stay, hours | 64 | 67 | 58 | 0.567 |
€
Pearson χ2 test for categorical variables, and t-test for continuous variables.
λ
Included 104 cases of HAdV-B, 114 cases of HAdV-C, 9 cases of HAdV-E and 10 cases with co-detection between HAdV species.
§
Underlying medical condition includes chronic pulmonary disease, asthma, airway disease, cardiac disease, renal disease, gastrointestinal disease, endocrine disease, blood disease including sickle cell anemia, immunodeficiency including asplenia, neurological conditions, Trisomy-21, genetic and metabolic disease, complex care patients.