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. Author manuscript; available in PMC: 2022 Jun 12.
Published in final edited form as: Angew Chem Int Ed Engl. 2021 Jun 14;60(29):15905–15911. doi: 10.1002/anie.202101328

Table 2.

Biochemical IC50s of FIIN2- IMiDs based degraders.

graphic file with name nihms-1705093-t0014.jpg
Compound Linker E3 binder FGFR2 IC50 (nM)[a]
DGY-09-068 graphic file with name nihms-1705093-t0015.jpg A 93
DGY-09-074 graphic file with name nihms-1705093-t0016.jpg B 42
DGY-09-077 graphic file with name nihms-1705093-t0017.jpg A 72
[a]

All the IC50s are measured by Z’-LYTE kinase assay by Invitrogen.