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. 2021 Jul 16;12:706902. doi: 10.3389/fgene.2021.706902

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Copyright © 2021 Pavel, Glickman, Michels, Kim-Schulze, Miller and Guttman-Yassky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Mean difference in Th2 and Th1 enrichment scores in the sputum of healthy individuals (CTRL) and severe asthma patients stratified by age. Horizontal bars denote standard error. (B) Mean difference in Th2 and Th1 enrichment scores in sputum of healthy individuals (CTRL) and of asthma patients in both males (M) and females (F) stratified by age. Horizontal bars denote standard error. (C) Correlation scatterplot between Th2/Th1 enrichment score and ACE2 gene expression in healthy individuals. Gray shaded area denotes the 95% confidence interval. Pearson correlation coefficient and p-value are provided. (D) Mean difference in Th2 and Th1 enrichment scores in nasal epithelium of healthy smokers and healthy never smokers. Horizontal bars denote standard error. +p < 0.1, *p < 0.05, **p < 0.01.