TABLE 2.

Odds ratios of risk profiles with colorectal neoplasm, non-advanced adenoma, and advanced neoplasm stratified by sex.

	Any neoplasm		Non-advanced adenoma		Advanced neoplasm
	No. of cases/no. of controls	OR (95% CI)	No. of cases/no. of controls	OR (95% CI)	No. of cases/no. of controls	OR (95% CI)
Male
Favorable lifestyle and lower PRS	166/264	1	118/264	1	48/264	1
Favorable lifestyle and higher PRS	28/22	2.01 (1.11–3.64)	21/22	2.12 (1.12–4.02)	7/22	1.73 (0.70–4.28)
Unfavorable lifestyle and lower PRS	219/205	1.71 (1.30–2.25)	144/205	1.59 (1.17–2.15)	75/205	2.01 (1.34–3.02)
Unfavorable lifestyle and higher PRS	38/22	2.87 (1.64–5.04)	23/22	2.41 (1.29–4.51)	15/22	3.96 (1.91–8.22)
Female
Favorable lifestyle and lower PRS	52/270	1	40/270	1	12/270	1
Favorable lifestyle and higher PRS	9/22	2.14 (0.93–4.92)	7/22	2.18 (0.87–5.45)	2/22	2.05 (0.43–9.76)
Unfavorable lifestyle and lower PRS	135/381	1.86 (1.30–2.65)	94/381	1.69 (1.13–2.53)	41/381	2.43 (1.25–4.71)
Unfavorable lifestyle and higher PRS	20/27	3.79 (1.98–7.28)	17/27	4.26 (2.13–8.53)	3/27	2.50 (0.67–9.42)

PRS: polygenic risk score; OR: odds ratio; CI: confidence interval.

Lifestyle was binarized as favorable and unfavorable according to the median of the lifestyle score.

Genetic risk was categorized as lower and higher according to the 90th percentile of the polygenic risk score.