TABLE 3.
10-year absolute risk estimates of colorectal neoplasm for 50-year-old men and women.
| Subgroup | 10-year absolute risk (95% CI) | |
|---|---|---|
| Men | Women | |
| Favorable lifestyle | ||
| Lower PRS | 2.80 (2.78–2.81) | 2.24 (2.21–2.27) |
| Higher PRS | 6.12 (6.04–6.20) | 4.08 (4.00–4.16) |
| Unfavorable lifestyle | ||
| Lower PRS | 4.56 (4.54–4.58) | 3.60 (3.58–3.62) |
| Higher PRS | 6.59 (6.53–6.65) | 4.19 (4.11–4.28) |
Abbreviations: CI, confidence interval: PRS, polygenic risk score.
Lifestyle was binarized as favorable and unfavorable according to the median of the lifestyle score.
Genetic risk was categorized as lower and higher according to the 90th percentile of the polygenic risk score.