Table 3.

Summary metrics from screening of high-risk individuals in test set using (i) a Cox-only approach, (ii) a GBT-only approach, and (iii) an ensemble approach in which a decision tree selects between Cox and GBT in cases of disagreement over an individual’s risk classification

	Men			Women
Metric	Cox-Only	GBT-Only	Ensemble	Cox-Only	GBT-Only	Ensemble
	[95% CI]	[95% CI]	[95% CI]	[95% CI]	[95% CI]	[95% CI]
Sensitivity	76%	80%	76%	68%	74%	67%
	[72%–80%]	[76%–84%]	[72%–80%]	[64%–72%]	[70%–78%]	[64%–71%]
Specificity	75%	74%	76%	80%	78%	81%
	[74%–77%]	[73%–76%]	[75%–78%]	[79%–81%]	[77%–79%]	[80%–82%]
PPV	25%	25%	26%	24%	23%	24%
	[23%–27%]	[23%–28%]	[23%–28%]	[22%–26%]	[21%–25%]	[22%–26%]
NPV	97%	97%	97%	97%	97%	97%
	[96%–97%]	[96%–98%]	[96%–97%]	[96%–97%]	[97%–98%]	[96%–97%]
Accuracy	75%	75%	76%	79%	77%	80%
	[74%–77%]	[74%–76%]	[75%–77%]	[78%–80%]	[76%–78%]	[79%–81%]