Fig. 1.

Association of Patient Mindfulness with Cognitive Performance and Hippocampal Volumes. Scatterplots are shown for cognitively normal controls (blue circles), MCI (red circles), and dementia (green circles) with fitted regression lines for the three subgroups. Panel 1A demonstrates the association between AMPS scores (y-axis) and self-rated global performance measured with patient QDRS (x-axis). Higher AMPS scores are moderately associated with better self-rated cognitive status in cognitively normal controls (R = 0.384, p < 0.001), MCI (R = 0.396, p < 0.001), and dementia cases (R = 0.409, p < 0.001). Panel 1B depicts the association between AMPS scores (y-axis) and depression measured by the HADS. Higher AMPS scores are strongly associated with fewer depression symptoms in cognitively normal controls (R = 0.503, p < 0.001) and MCI (R = 0.512, p < 0.001) but not in in dementia cases (R = 0.216). Panel 1C demonstrates the association between AMPS scores (y-axis) and overall cognitive performance measured by the MoCA (x-axis). Higher AMPS scores are moderately associated with better cognitive performance in cognitively normal controls (R = 0.306, p < 0.001) but not in MCI (R = 0.089) or dementia cases (R = 0.032). Panel 1D shows the association between AMPS scores (y-axis) and hippocampal volumes (x-axis). Higher AMPS scores are moderately correlated with larger hippocampal volumes in cognitively normal controls (R = 0.349, p < 0.001) but not in MCI (R = 0.145) or dementia cases (R = 0.275).