Skip to main content
. Author manuscript; available in PMC: 2021 Jul 30.
Published in final edited form as: Parkinsonism Relat Disord. 2021 Jan 30;84:35–39. doi: 10.1016/j.parkreldis.2021.01.022

Table 1.

Clinically actionable information required for precise identification of therapeutic goals and example medication adjustments to optimize PD control.

Clinically Actionable Information Therapeutic Goals Examples of Medication Adjustments
Duration of OFF state Reduce OFF time (longer time spent in ON time with each dose) Add COMT-I, MAO-I, new dopaminergic medication, increase dose of existing dopaminergic medication, reducing interval of dopaminergic medication dosing
Duration of ON state
Change in MDS-UPDRS-III severity between OFF and ON states Improve quality of ON time (greater degree of symptom improvement with each dose) Increase dose of dopaminergic medication, add a new dopaminergic medication, add trihexyphenidyl (for tremor only)
Change in tremor severity from OFF and ON states
Duration of OND state Reduce dyskinesia severity or duration Add amantadine or lower dose of dopaminergic medication
Change in dyskinesia severity from OFF and ON states