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. Author manuscript; available in PMC: 2021 Jul 30.
Published in final edited form as: Toxicology. 2019 Dec 13;430:152345. doi: 10.1016/j.tox.2019.152345

Table 1.

The top 10 dysregulated biological pathways at immediate (2 h), early (26 h) and late (day 4) response in IC following acute H2S exposure.

Exposure Pathway pValue z-Score
Immediate response Unfolded protein response 1.05E-06
Immediate response Catecholamine Biosynthesis 6.72E-05
Immediate response Coagulation System 2.48E-04
Immediate response GADD45 Signaling 1.25E-03
Immediate response Dopamine Receptor Signaling 3.73E-03
Immediate response NRF2-mediated Oxidative Stress Response 4.51E-03 1.342
Immediate response GABA Receptor Signaling 7.61E-03 1
Immediate response Death Receptor Signaling 9.78E-03 0.378
Immediate response eNOS Signaling 1.95E-02 0.707
Immediate response p53 Signaling 2.51E-02 2
Early response Unfolded protein response 2.05E-07
Early response NRF2-mediated Oxidative Stress Response 8.26E-05 0.447
Early response Hypoxia Signaling in the Cardiovascular System 8.94E-05 1.633
Early response Coagulation System 2.44E-04 −0.447
Early response Endoplasmic Reticulum Stress Pathway 3.34E-04
Early response Acute Phase Response Signaling 4.74E-04 2.646
Early response PI3K Signaling in B Lymphocytes 5.08E-03 0.816
Early response Calcium Signaling 9.02E-03 −0.447
Early response IL-6 Signaling 1.80E-02 0.816
Early response HMGB1 Signaling 2.20E-02 1.342
Late response Agranulocyte Adhesion and Diapedesis 1.55E-10
Late response Granulocyte Adhesion and Diapedesis 1.08E-08
Late response Acute Phase Response Signaling 1.67E-07 2.887
Late response HMGB1 Signaling 2.00E-07 2.673
Late response IL-10 Signaling 2.18E-07
Late response Coagulation System 8.45E-06 −1.134
Late response phagosome formation 1.38E-05
Late response IL-6 Signaling 1.01E-04 1.897
Late response JAK/Stat Signaling 4.32E-04 0.707
Late response PPAR Signaling 9.24E-04 −2.828

Dysregulated biological pathways were analyzed for immediate, early, and late response to H2S exposure. The top 10 dysregulated biological pathways were measured by statistical analyses and are listed. Degree of activating biological pathways is shown by the z-Score. Higher value of z-Score indicates activation of biological pathways, whereas lower value of z-Score for inactivation of biological pathways.