Table 2.
Potential upstream regulators in the IC responding to acute H2S exposure.
| Immediate response | TNF | 3.96e-23 | 2.178 |
| Immediate response | LPS | 5.94e-20 | 3.084 |
| Immediate response | PDGF BB | 2.36e-19 | 3.645 |
| Immediate response | CREB1 | 6.95e-19 | 3.669 |
| Immediate response | PKC | 6.86e-18 | 3.69 |
| Immediate response | TGF-β1 | 1.94e-17 | 3.8 |
| Immediate response | FGF2 | 6.87e-17 | 1.562 |
| Immediate response | EGFR | 8.33e-17 | 1.339 |
| Immediate response | TP53 | 5.13e-15 | 3.049 |
| Immediate response | IL 1b | 7.39e-15 | 3.299 |
| Early response | LPS | 6.19e-21 | 2.849 |
| Early response | IL-1β | 7.55e-20 | 2.736 |
| Early response | CREB1 | 5.86e-19 | 2.722 |
| Early response | D-glucose | 6.26e-18 | 3.197 |
| Early response | IGF1 | 9.02e-18 | 3.395 |
| Early response | TGF-β1 | 9.27e-18 | 3.933 |
| Early response | PDGF BB | 2.75e-17 | 3.758 |
| Early response | TNF | 7.54e-16 | 1.704 |
| Early response | TP53 | 1.42e-15 | 2.525 |
| Early response | Insulin | 7.25e-15 | 2.602 |
| Late response | LPS | 7.73e-64 | 8.368 |
| Late response | TNF | 7.73e-55 | 5.13 |
| Late response | TGF-β1 | 1.47e-47 | 5.157 |
| Late response | IFN-γ | 3.15e-45 | 7.274 |
| Late response | IL-1β | 3.25e-42 | 5.658 |
| Late response | STAT3 | 2.0e-40 | 2.884 |
| Late response | IL4 | 1.63e-36 | 3.725 |
| Late response | IL6 | 1.29e-32 | 5.893 |
| Late response | U0126 | 2.78e-30 | −5.359 |
| Late response | PDGF BB | 4.26e-28 | 5.277 |
Potential upstream regulators were analyzed at immediate (2 h), early (26 h), and late response (day 4) to acute H2S exposure. The top 10 potential upstream regulators were statistically analyzed and are listed. Degree of activating biological pathways is shown by z-Score. Higher value of z-Score indicates activation of potential upstream regulator, whereas lower value of z-Score for inactivation of potential upstream regulator.