Table 3.
Adverse events in 3 groups.
| DOX 93 | XELOX 92 | Surgery 95 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Grades 1-2 | Grade 3 | Grade 4 | Grades 1-2 | Grade 3 | Grade 4 | Grades 1-2 | Grade 3 | Grade 4 | |
| Gastrointestinal disorders | |||||||||
| Nausea | 41 | 14 | 0 | 36 | 15 | 0 | 38 | 12 | 0 |
| Vomiting | 20 | 4 | 0 | 10 | 2 | 0 | 12 | 0 | 0 |
| Diarrhea | 34 | 6 | 0 | 26 | 2 | 0 | 16 | 6 | 0 |
| Constipation | 8 | 0 | 0 | 8 | 0 | 0 | 4 | 0 | 0 |
| Decreased appetite | 46 | 8 | 0 | 38 | 8 | 0 | 40 | 6 | 0 |
| Dysphagia | |||||||||
| Blood and lymphatic system disorders | |||||||||
| Anemia | 44 | 6 | 2 | 44 | 2 | 0 | 38 | 4 | 0 |
| Leucopenia | 54 | 16 | 4 | 50 | 17 | 4 | 46 | 15 | 0 |
| Neutropenia | 59 | 24 | 6 | 48 | 26 | 2 | 40 | 18 | 2 |
| Thrombocytopenia | 22 | 4 | 2 | 16 | 0 | 0 | 18 | 0 | 0 |
| Febrile neutropenia | NA | 2 | 0 | NA | 0 | 0 | NA | 0 | 0 |
| General and other disorders | |||||||||
| Neurotoxic effects | 14 | 0 | 0 | 12 | 0 | 0 | 8 | 0 | 0 |
| Fatigue | 46 | 10 | 0 | 38 | 7 | 0 | 34 | 8 | 0 |
| Alopecia | 58 | NA | NA | 0 | NA | NA | 0 | NA | NA |
| Weight decreased | 34 | 4 | 0 | 38 | 0 | 0 | 28 | 0 | 0 |
| Skin effects | 8 | 0 | 0 | 4 | 0 | 0 | 2 | 0 | 0 |
| Laboratory | |||||||||
| ALT elevation | 14 | 2 | 0 | 10 | 0 | 0 | 8 | 0 | 0 |
| GOT elevation | 10 | 2 | 0 | 12 | 0 | 0 | 10 | 0 | 0 |