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. 2021 Jul 23;2021:9987383. doi: 10.1155/2021/9987383

Figure 3.

Figure 3

Effect of HIF-1α RNAi combined with ASP on the expression of MAPK and PI3K signaling pathway-related proteins. (a) Relative expression of HIF-1α and VEGF mRNA analyzed using qPCR. ∗∗P < 0.01 and ∗∗∗P < 0.001 versus control group. #P < 0.05, ##P < 0.01, and ###P < 0.001 versus LV-shHIF1α + ASP group. (b)-(c) Protein levels of HIF-1α, VEGF, AKT, p-AKT, ERK, and p-ERK assessed using western blot. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001 versus control group. #P < 0.05, ##P < 0.01, and ###P < 0.001 versus LV-shHIF1α + ASP group.