Table 2.

Animal studies of B. longum strain effects in modulating inflammation.

Strains	Dose	Model	Effect	Ref.
B. longum Bif10 and Bif16	5 × 109 CFU/mouse/day	DSS-induced colitis in mice	SCFA ↑ TNF-α, IL-1β, IL-6 ↓	[59]
B. longum 5 (1A)	1 × 108 CFU/mouse/day	DSS-induced colitis in mice	IL-1 ↓ MPO ↓	[40]
B. longum YS108R	1 × 109 CFU/mouse/day	DSS-induced colitis in mice	IL-10 ↑ TNF-α, MPO, IL-1β, IL-6, IL-17A ↓	[24, 72]
B. longum ATCC 15707	1 × 107 CFU/kg/day	DSS-induced colitis in mice	SCFA ↑ TNF-α, IL-6, TGF-β ↓	[71]
B. longum HB5502	4 × 109 CFU/day	TNBS-induced colitis in mice	HMGB1 ↓	[84]
B. Longum LC67	1 × 109 CFU/mouse/day	Ethanol-induced gastritis in mice	NF-κB, CXCL4, TNF ↓	[41]
B. longum LC67	1 × 109 CFU/mouse/day	High-fat diet-induced colitis in mice	AMPK ↑ NF-κB ↓	[74]
B. longum LC67	1 × 109 CFU/mouse/day	TNBS-induced colitis in mice	NF-κB, MPO ↓	[79]