Table 4.
Estimated odds ratio (OR) along with 95% confidence interval (CI) estimated from univariable logistic regression models on the association between patient and tumor factors and the chance of receiving perioperative radiotherapy for grade II and III resected soft tissue sarcoma in the Netherlands between 2000 and 2017.
| Factor | OR | 95% CI | p value |
|---|---|---|---|
| Age (continuous) | 0.982 | 0.979–0.986 | <0.001∗ |
| Sex | 0.030∗ | ||
| Female sex (ref.) | — | — | |
| Male sex | 1.132 | 1.012–1.266 | |
|
| |||
| Location | <0.001∗ | ||
| Lower extremity (ref.) | — | — | |
| Upper extremity | 0.769 | 0.645–0.916 | |
| Head & neck | 0.231 | 0.192–0.278 | |
| Trunk | 0.376 | 0.328–0.431 | |
| Heart/mediastinum/pleura | 0.255 | 0.132–0.494 | |
|
| |||
| Subtype | <0.001∗ | ||
| UPS (ref.) | — | — | |
| Myxofibrosarcoma | 2.346 | 1.878–2.929 | |
| Leiomyosarcoma | 0.754 | 0.615–0.926 | |
| Angiosarcoma | 0.283 | 0.216–0.371 | |
| MPNST | 1.062 | 0.823–1.370 | |
| Synovial sarcoma | 1.866 | 1.415–2.462 | |
| MLS | 2.665 | 2.087–3.404 | |
| Pleomorphic liposarcoma | 1.827 | 1.249–2.671 | |
| Dedifferentiated liposarcoma | 0.857 | 0.638–1.151 | |
| Liposarcomas NOS | 1.370 | 0.846–2.219 | |
| Rest category | 0.885 | 0.734–1.068 | |
|
| |||
| Grade | 0.009∗ | ||
| Intermediate grade II (ref.) | — | — | |
| High grade III | 1.170 | 1.040–1.315 | |
|
| |||
| Tumor size | <0.001∗ | ||
| ≤5 cm (ref.) | — | — | |
| >5 cm | 2.418 | 2.122–2.756 | |
|
| |||
| Tumor depth | <0.001∗ | ||
| Superficial depth (ref.) | — | — | |
| Deep depth | 1.660 | 1.465–1.880 | |
Abbreviations: OR=odds ratio, CI=confidence interval, ref. = reference, UPS = undifferentiated pleomorphic sarcoma, MPNST = malignant peripheral nerve sheath tumor, MLS = myxoid liposarcoma, NOS = not otherwise specified. ∗p < 0.05.