Table 2.

Antiepileptic effect of CPM on PTZ induced seizure in mice.

Treatment	Seizure latency (s)	Death latency (s)	Seizure rate (%)	Death rate (%)
Model	83.56 ± 22.51	197.28 ± 30.18	100	100
Positive	1800 ± 0∗∗	1800 ± 0∗∗	0∗∗	0∗∗
100 mg/kg	85.10 ± 19.26	208.54 ± 31.57	100	100
200 mg/kg	124.25 ± 20.67∗	383.10 ± 49.38∗∗	100	70∗
400 mg/kg	209.90 ± 26.29∗∗	452.62 ± 65.12∗∗	100	40∗∗

PTZ: pentylenetetrazole; CPM: Cicadae Periostracum. Diazepam was used as a positive control. Mice were divided into five groups (n = 20): model group (mice were treated with normal saline, 20 mL/kg, p.o.), positive group (mice were treated with diazepam, 4 mg/kg, i.p.), and three tested CPM groups (mice were treated with CPM at the doses of 100, 200, and 400 mg/kg, p.o.). The chi-squared test was used to analyze significance of anticonvulsant effects against PTZ-induced seizures among groups (inhibition (%) and mortality (%)). All other data were presented as mean ± SD (n = 20), and statistical analyses were performed using the two-tailed Student's t test, ^∗p < 0.05 and ^∗∗p < 0.01 vs. model.