Figure 5.

BAT is associated with improved markers of hepatic steatosis and T2DM

(A) Illustration of liver density (HU) measurement as a surrogate for fatty liver disease.

(B) Association of liver density based on HU measurements and SAT:VAT ratio. β-Estimate and p value were calculated using linear regression analysis. The best fit curve was derived from measurements of 1,298 individuals and is shown up to a SAT:VAT ratio of 7.8.

(C) Boxplot of mean liver HUs stratified by BAT status. Boxes represent the 25th percentile, median, and 75th percentile, and whiskers illustrate the 10th and 90th percentiles. The p value is calculated based on a Mann-Whitney U test. The depicted data show measurements for 1,298 individuals.

(D) Best fit curves of mean liver HUs across SAT:VAT ratios, stratified by BAT status, were calculated using linear regression analysis, and shaded areas depict 95% CIs. The best fit curves were derived from measurements of 1,298 individuals and are shown up to a SAT:VAT ratio of 7.8.

(E) Prevalence of T2DM stratified by BAT status. Data are shown for 1,702 individuals.

(F) Best fit curve of the probability of T2DM across SAT:VAT ratios was calculated using logistic regression analysis, and shaded area depicts the 95% CI. OR and p value correspond to the logistic regression model. The best fit curve was derived from measurements of 1,702 individuals and is shown up to a SAT:VAT ratio of 7.8.

(G) Best fit curves of the probability of T2DM across SAT:VAT ratios, stratified by BAT status, were calculated using logistic regression analysis, and shaded areas depict the 95% CI. ORs and p values correspond to the logistic regression model. The best fit curves were derived from measurements of 1,702 individuals and are shown up to a SAT:VAT ratio of 7.8.