Figure 1.

Single-cell transcriptomic profiling of TPCs from normal and diseased samples under mechanical stretching reveals heterogeneous subpopulations

(A) Overview of stretching and scRNA-seq experiment.

(B) UMAP plot of 11,298 cells from healthy and disease patients. Chart to the right displays association of TPC subsets with either the normal or the diseased cohort. Data represent three biological replicates per cohort, and both normal and diseased cohorts are shown.

(C) UMAP plots of cells from the normal cohort and diseased cohort. (Bottom) Cohort association for each cluster. Data represent 3 biological replicates per cohort, and both normal and diseased cohorts are shown separately.

(D) Pearson correlation matrix examining patient to patient similarity. Scale bar indicates pearson correlation.