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. 2021 Jul 21;2(7):100345. doi: 10.1016/j.xcrm.2021.100345

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© 2021 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Paired RNA-seq from sensory neurons showing an age-dependent effect of differential expression between genotypes

(A and B) RNA-seq of young (8 week) (A) and old (B) iPSCd sensory neurons; HSN1 versus healthy controls. Volcano plots showing the range of differential expression of genes between HSN1 and control iPSCdSNs at 8 weeks (A) and 26 weeks (B) after differentiation. Significance is color coded. The number of significantly up/downregulated differentially expressed (DE) genes is annotated in each plot.

(C) Selected significantly enriched biological processes (GO terms) in HSN1 versus healthy, old controls. The number of DE genes in the category is encoded in the dot size; the percentage of the category’s genes that are DE is shown on x axis. p value is color coded.