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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: J Thromb Haemost. 2021 May 11;19(8):1888–1895. doi: 10.1111/jth.15332

Table 2.

scFv4–20-mediated inhibition of ADAMTS13 activity in the presence and absence of scFv3–3

Assay conditions pH 6.0 and 25 °C pH 7.45 and 37 °C
[scFv3–3] 0
 IC50 (nM) 0.64 ± 0.03* NA
 Hill coeffi. 1.54 ± 0.09 NA
[scFv3–3] 1.25 nM
 IC50 (nM) 0.48 ± 0.01 0.29 ± 0.02
 Hill coeffi. 2.14 ± 0.14 2.26 ± 0.21
[scFv3–3] 5.0 nM
 IC50 (nM) 0.39 ± 0.04 0.61 ± 0.09
 Hill coeffi. 1.74 ± 0.18 5.67 ± 1.17
*

All data are presented as the mean ± SEM; NA, not determined.

Temp., Temperature; coeffi., coefficient.