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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Trends Immunol. 2021 Jul 6;42(8):658–669. doi: 10.1016/j.it.2021.06.003

Figure 1: Nomenclature used for CD4+ T cells that help B cells in different anatomic locations in mice and humans.

Figure 1:

Left, Tfh and Tfh-like subsets are shown in regions of secondary lymphoid organs (SLOs) with particular functions depicted. Shown is a region of a lymph node, although similar structures exist in other SLOs. Extrafollicular T follicular helper (EFTfh); T follicular regulatory (Tfr); Natural killer Tfh (NKTfh); Secondary lymphoid organ Tfh (SLO Tfh); Plasmablast (PB); Antibody secreting cell (ASC); Germinal center B cell (GCB); Memory B (mB). Right, Tfh and related subsets in tissues and the blood with general anatomic distinctions and select functions indicated. Circulating Tfh (cTfh); T peripheral helper (Tph); T resident helper (Trh).