Fig. 6. Innate homing and Vγ9/CD123 bispecific mediated anti-tumor activity of Vγ9⁺ (γδ) T cells in KG-1 xenograft model.

a NOD-SCID mice were engrafted subcutaneously with KG-1 cells and were treated with PBS alone or expanded γδ T cells alone or expanded γδ T cells Vγ9/CD123 bispecific antibody. Expanded γδ were infused to the mice very week for four times. The table represents the percentage of tumor growth inhibition for all groups on day 24 of the experiment. b Fluorescence intensity in representative images refers to the abundance of adoptively transferred Dil dye-labelled Vγ9⁺ γδ T cells in various organs of mice with established KG-1 tumors (~1000 mm³). n = 6 mice for each group from a single experiment and 2–4 mice from two independent experiments. Statistical significance was calculated using two-way ANOVA followed by Bonferroni’s post-test. p ≤ 0.05 were considered as a statistically significant difference between groups (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, and ns suggests p > 0.05).