| There were significant increasing trends of opioid overdose at the US inpatient care setting from 2009 to 2017, showing an ongoing need for opioid overdose prevention |
| Different prescription opioids were associated with opioid overdose to different extents, indicating a necessity to differentiate prescription opioids during prescribing |
| The optimal properties underlying reduced overdose effects mined from the large-scale, real-world electronic health records hold significant potential to guide the development of better opioids with reduced overdose effects |
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