Figure 5.

While NAFLD is defined by LD accumulation, the location of LDs matters. (Upper right) LD size and composition can vary widely across hepatic sinusoids. (Lower right) In addition to hepatocytes, LDs can also accumulate in endothelial cells, HSCs, and Kupffer cells. (Lower left) LDs interact with numerous organelles such as the ER, mitochondria, and peroxisomes to coordinate lipid trafficking and compartmentalize cell signaling. LDs are also present in the nucleus under certain conditions, although the significance of this LD pool is largely undetermined.