Table 3.

Alterations in liver function indices with different therapeutic agents.

	ALT	AST	ALP	GGT	Albumin	Bilirubin	Ref
Bicyclol	↓	–	N	–	N	N	[12]
Cysteamine Bitartrate (CB)	↓	↓	–	↓	N	N	[16]
l-carnitine	↓	↓	N	↓	–	N	[23]
Liraglutide	–	–	–	↓	–	–	[29]
Metformin	↓	↓					[32]
Obeticholic acid	↓	↓	↑	↓	–	↓	[37,38]
Pentoxifylline	↓	–	N	N	N	N	[44]
Pioglitazone	↓	↓	↓	↓	↓	–	[46,47] [48,49]
Prebiotic (Bifidobacterium longum with fructo-oligosaccharides)	–	↓	N	N	–	–	[52]
Selonsertib	↓	↓	N	↓	N	N	[57]
UDCA	↓	–	N	↓	N	N	[61,62]
DHA Plus Vitamin D	↓	↓	N	–	N	N	[19]
DHA Plus Vitamin E & choline	↓	–	N	–	N	N	[20]
UDCA Plus Vitamin E	↓	↓	N	N	N	N	[62]
Elafibranor	↓	N	↓	↓	N	N	[65]
Resmetirom	↓	↓	–	↓	–	–	[39]

N: Not determined.

↑: Increase.

↓: Decrease.

–: Not significantly affected.

ALP: Alkaline phosphatase, ALT: Alanine transaminase, AST: Aspartate transaminase, DHA: Docosahexaenoic Acid, GGT: Gamma glutamyl transpeptidase, UDCA: Ursodeoxycholic acid.