Table 1.
Baseline characteristics of AF patients on oral anticoagulation by types of antidepressant, MarketScan®, 2007–2015
| SSRI | SNRI | SRI | TCA | Other | |
|---|---|---|---|---|---|
| N (%) | 16830 (56) | 3023 (10) | 3486 (12) | 2971 (10) | 4026 (13) |
| Mean (SD) | |||||
| Age | 71.8 (13.2) | 70.9 (12.3) | 73.6 (12.6) | 70.8 (12.4) | 74.5 (13.4) |
| HAS-BLED Score | 2.5 (1.3) | 2.5 (1.3) | 2.6 (1.3) | 2.4 (1.3) | 2.7 (1.3) |
| CHA2DS2-VASc | 4.3 (2.1) | 4.2 (2.1) | 4.3 (2.0) | 4.0 (2.0) | 4.5 (2.1) |
| N (%) | |||||
| Female | 8838 (53) | 1570 (52) | 2077 (60) | 1643 (55) | 2224 (55) |
| HF | 7584 (45) | 1358 (45) | 1700 (49) | 1187 (40) | 2050 (51) |
| Hypertension | 14220 (84) | 2618 (87) | 3041 (87) | 2473 (83) | 3431 (85) |
| DM | 6187 (37) | 1339 (44) | 1265 (36) | 1104 (37) | 1425 (35) |
| MI | 2361 (14) | 401 (13) | 561 (16) | 362 (12) | 609 (15) |
| PAD | 3930 (23) | 790 (26) | 866 (25) | 675 (23) | 1124 (28) |
| Kidney failure | 2861 (17) | 522 (17) | 724 (21) | 491 (17) | 844 (21) |
| Stroke | 5597 (33) | 921 (30) | 1080 (31) | 867 (29) | 1426 (35) |
| Bleeding (all types) | 6332 (38) | 1104 (37) | 1300 (37) | 1051 (35) | 1643 (41) |
| Intracranial or GI bleeding | 301 (2) | 49 (2) | 58 (1) | 50 (1) | 60 (1) |
| Anemia | 5607 (33) | 1105 (37) | 1272 (36) | 972 (33) | 1576 (39) |
| Coagulopathy | 2346 (14) | 440 (15) | 472 (14) | 436 (15) | 615 (15) |
| Cancer | 3343 (20) | 632 (21) | 722 (21) | 600 (20) | 940 (23) |
| Mood disorder | 4592 (27) | 782 (26) | 478 (14) | 266 (9) | 1143 (28) |
| Cognitive impairment | 1675 (10) | 234 (8) | 356 (10) | 153 (5) | 526 (13) |
| COPD | 6360 (38) | 1174 (39) | 1383 (40) | 1117 (38) | 1773 (44) |
| Liver | 1322 (8) | 285 (9) | 315 (9) | 319 (11) | 394 (10) |
| Alcohol | 485 (3) | 80 (3) | 148 (4) | 78 (3) | 161 (4) |
| Antiplatelet | 463 (3) | 87 (3) | 95 (3) | 82 (3) | 119 (3) |
| Diuretics | 9940 (59) | 1854 (61) | 2160 (62) | 1739 (59) | 2418 (60) |
| Antiarrhythmic | 2155 (13) | 377 (12) | 434 (12) | 425 (14) | 488 (12) |
| Digoxin | 4602 (27) | 807 (27) | 937 (27) | 807 (27) | 1212 (30) |
| ACEI | 7513 (45) | 1284 (42) | 1635 (47) | 1286 (43) | 1784 (44) |
| ARB | 4671 (28) | 872 (29) | 1018 (29) | 828 (28) | 1052 (26) |
| Beta-blocker | 13265 (79) | 2378 (79) | 2823 (81) | 2347 (79) | 3172 (79) |
| Calcium channel blocker | 8144 (48) | 1423 (47) | 1704 (49) | 1484 (50) | 1913 (48) |
| Lipid-lowering medications | 10898 (65) | 1964 (65) | 2334 (67) | 1923 (65) | 2502 (62) |
| Warfarin | 13652 (81) | 2369 (78) | 2777 (80) | 2482 (84) | 3214 (80) |
| Apixaban | 467 (3) | 89 (3) | 107 (3) | 63 (2) | 126 (3) |
| Rivaroxaban | 1307 (8) | 282 (9) | 318 (9) | 221 (7) | 359 (9) |
| Dabigatran | 1403 (8) | 282 (9) | 284 (8) | 205 (7) | 327 (8) |
ACEI angiotensin-converting-enzyme inhibitor, ARB angiotensin receptor blockers, COPD chronic obstructive pulmonary disease, DM diabetes mellitus, GI gastrointestinal, HF heart failure, HTN hypertension, MI myocardial infarction, Other other antidepressants, PAD peripheral arterial diseases, SNRI serotonin/norepinephrine reuptake inhibitor, SRI serotonin reuptake inhibitor, SSRI selective serotonin reuptake inhibitor, TCA tricyclic antidepressant