Among atrial fibrillation patients taking oral anticoagulants, initiation of selective serotonin reuptake inhibitors was associated with an increased risk of bleeding when compared to most other types of antidepressants.

Among atrial fibrillation patients taking oral anticoagulants, initiation of serotonin/norepinephrine reuptake inhibitor was associated with the lowest bleeding risk.

Associations observed in this study did not differ by sex, age, or the type of oral anticoagulant used.