Table 2.
Prescription of QT-prolonging drugs (more than two prescriptions) stratified by risk category and therapeutic classes
| QT-prolonging drugs with more than two prescriptions | Number of prescriptions (n = 498) | TdP risk listsa |
|---|---|---|
| Antimicrobials | ||
| Piperacillin/tazobactam | 34 (6.8) | 3 |
| Clarithromycin | 19 (3.8) | 1 |
| Metronidazole | 11 (2.2) | 3 |
| Levofloxacin | 10 (2.0) | 1 |
| Ciprofloxacin | 6 (1.2) | 1 |
| Antidepressants | ||
| Citalopram | 11 (2.2) | 1 |
| Sertraline | 11 (2.2) | 3 |
| Paroxetine | 9 (1.8) | 3 |
| Venlafaxine | 7 (1.4) | 2 |
| Escitalopram | 4 (0.8) | 1 |
| Mirtazapine | 4 (0.8) | 2 |
| Trazodone | 3 (0.6) | 3 |
| Cardiovascular | ||
| Furosemide | 121 (24.3) | 3 |
| Amiodarone | 13 (2.6) | 1 |
| Flecainide | 4 (0.8) | 1 |
| Ranolazine | 4 (0.8) | 2 |
| Valsartan/hydrochlorothiazide | 4 (0.8) | 3 |
| Ivabradine | 3 (0.6) | 3 |
| Ramipril/hydrochlorothiazide | 3 (0.6) | 3 |
| Perindopril/indapamide | 3 (0.6) | 3 |
| Proton pump inhibitors | ||
| Pantoprazole | 91 (18.3) | 3 |
| Lansoprazole | 35 (7.0) | 3 |
| Omeprazole | 22 (4.4) | 3 |
| Esomeprazole | 6 (1.2) | 3 |
| Others | ||
| Metoclopramide | 6 (1.2) | 3 |
| Quetiapine | 5 (1.0) | 3 |
| Alfuzosin | 5 (1.0) | 2 |
Data are presented as n (%) unless otherwise indicated
aClassification from https://www.crediblemeds.org. List 1 = drugs with known risk of torsade de pointes; list 2 = drugs with possible risk of torsade de pointes; list 3 = drugs with conditional risk of torsade de pointes