. 2021 Jul 30;11:15531. doi: 10.1038/s41598-021-94719-y

Table 1.

Vaccine efficacy profiles simulated in the main analysis.

Vaccine efficacy profiles	Vaccine 1	Vaccine 2	Vaccine 3	Vaccine 4
Vaccine effects on susceptibility (VE_SUSC) defined as reduction of the probability to acquire infection upon exposure	0.1	0.4	0.1	0.8
Vaccine effects on symptomatology (VE_SYMP) defined as reduction in the probability to develop symptoms upon infection	0.444	0.167	0.889	0.5
Vaccine effects on COVID-19 disease (VE_DIS) = 1 − (1 − VE_SUSC) (1 − VE_SYMP) defined as reduction in the likelihood to develop symptomatic diseases upon exposure	0.5	0.5	0.9	0.9

Vaccine efficacy profiles

Vaccine 1

Vaccine 2

Vaccine 3

Vaccine 4

Vaccine effects on susceptibility (VE_SUSC) defined as reduction of the probability to acquire infection upon exposure

0.1

0.4

0.1

0.8

Vaccine effects on symptomatology (VE_SYMP) defined as reduction in the probability to develop symptoms upon infection

0.444

0.167

0.889

0.5

Vaccine effects on COVID-19 disease

(VE_DIS) = 1 − (1 − VE_SUSC) (1 − VE_SYMP) defined as reduction in the likelihood to develop symptomatic diseases upon exposure

0.5

0.9

All profiles assume no reduction in infectiousness (VE_INF = 0).