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. 2021 Jul 30;4:928. doi: 10.1038/s42003-021-02427-0

Fig. 7. Acetate treatment after infection onset improves sepsis outcome.

Fig. 7

a Mice were treated with acetate (Ac) in PBS or an equal volume of PBS 6 h after the onset of an S. aureus bloodstream infection, and septic wild-type (black symbols) and GPR43−/− (blue symbols) mice were monitored for 4 days. b Acetate-treated wild-type mice regained weight more rapidly than PBS-treated wild-type mice. c This was accompanied by a reduced bacterial load in the liver when compared to PBS-treated septic mice. GPR43−/− mice displayed similar bacterial loads in the liver compared to PBS-treated wild-type mice (c). Acetate (Ac) treatment showed no effect in GPR43−/− mice. Data in panels b, c represent geometric means or geometric means ± SEM (b) from six animals. *P < 0.05; **P < 0.01 significant difference versus the indicated condition as calculated by one-way ANOVA with Dunnett’s multiple comparisons test (b) or by Mann–Whitney U test (c).