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. 2021 Jul 30;11:15572. doi: 10.1038/s41598-021-95066-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Prothrombin conversion in haemophilia A triggered with 5 pM tissue factor. Prothrombin conversion curves were determined from TG curves measured at 5 pM TF. (A) Average prothrombin conversion curves for the patient and control group. Individual TG curves were quantified by the total prothrombin conversion (PC_tot, B), maximum prothrombin conversion rate (PC_max, C), thrombin-antithrombin complex formation (T-AT, D), and thrombin-α₂macroglobulin complex formation (T-α₂M) (E). Prothrombin conversion curves are depicted as the mean curve (continuous line) ± the 95% confidence interval (dotted lines) and the parameter values are shown as the individual values with the median ± interquartile range. Statistical significance according to the Mann Whitney test is indicated as ** for a p-value < 0.01, **** for a p-value < 0.0001.