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. 2021 Jul 19;24(7):102713. doi: 10.1016/j.isci.2021.102713

Figure 3.

Figure 3

Broad RAGP anatomy of SAN-projecting and non SAN-projecting neurons

(A) Visualization within the 3D anatomical framework of both SAN-projecting (blue) and non SAN-projecting (purple) neurons that were comprehensively identified in select sections of a representative RAGP. Panels along the right side and bottom show density plots representing the density of projecting and non-projecting neurons along each axis. The bounding box on the lower panel shows 18.8 mm, 19.4 mm, and 16 mm on the x, y, and z axis, respectively.

(B) Anterior (top), angled (middle) and superior (bottom) views of a representative RAGP showing only the SAN-projecting neurons (left) or non SAN-projecting neurons (right). The X, Y, Z measurements are consistent with those in panel (A).

(C) A select section of the RAGP (7,040 μm from the superior aspect) zooming in on three different neuron clusters showing a high percentage of neurons within the cluster projecting to the SAN toward the SAN-proximal side of the RAGP (1), a cluster with no SAN-projecting neurons toward the SAN-distal side of the RAGP (3) and a cluster with a mix of both projecting and non-projecting neurons in between (2). Scale bars: 100 μm. Tissue measured 18.8 mm from left to right (xaxis) and 19.4 mm top to bottom (yaxis). For an animated visualization see Video S1.