Table 1.

Reactivation of nerve agent adducted acetylcholinesterase by LLNL-02 (1) and 2-PAM

Agent	Reactivation rate, kr (min−1)		Dissociation constant, KD (µM)		Overall reactivation rate, kr2 (min−1 M−1)
	2-PAM	LLNL-02	2-PAM	LLNL-02	2-PAM	LLNL-02
GB	0.06 ± 0.02	0.004 ± 0.0001	706 ± 135	551.4 ± 61.3	81 ± 16	6.8 ± 0.8
VX	0.06 ± 0.005	0.01 ± 0.0007	541 ± 155	656 ± 84	121 ± 29	20.4 ± 2.9

Oxime concentration ranged from 18 µM to 2 mM. Reaction time was 30 min.