Table 2.

Mean pharmacokinetic parameters of LLNL-02 (1) following a single IV administration of ¹⁴C-LLNL-02 to male guinea pigs.

Dose (mg/kg)	t1/2α (h)	t½β (h)	AUC0-t (µg h/mL)	AUC0-inf (µg h/mL)	Vd (mL/kg)	CL (mL/h/kg)
1	0.39 ± 0.01	21.92 ± 3.49	3.88 ± 0.42	7.20 ± 1.14	4402.28 ± 247.12	167.77 ± 46.53
5	0.40 ± 0.02	17.13 ± 2.69	20.52 ± 1.93	31.50 ± 4.61	3747.90 ± 228.94	178.64 ± 35.69
10	0.25 ± 0.03	9.61 ± 0.88	25.87 ± 2.15	30.50 ± 3.39	5132.86 ± 374.57	335.60 ± 34.98
20	0.39 ± 0.06	18.94 ± 5.75	51.72 ± 6.28	87.88 ± 25.49	5341 ± 473.22	311.07 ± 74.71

Data is expressed as the mean of six animals ± the standard error.